GLIAL-RESTRICTED PROGENITOR CELLS: A CURE FOR DISEASED BRAIN?

Abstract The central nervous system (CNS) is home to neuronal and glial cells.Traditionally, glia was disregarded as just the structural support across the brain and spinal cord, in striking contrast to neurons, always considered critical players in CNS functioning.In modern times this outdated dogma is continuously repelled by new evidence unravel

Pantothenate kinase-associated neurodegeneration, PKAN, is an inherited disorder characterized by progressive impairment in motor coordination and caused by mutations in PANK2, a human gene that encodes one of four pantothenate kinase (PanK) isoforms.PanK initiates the synthesis of coenzyme A (CoA), an essential cofactor that plays a key role in en